Background: We reviewed the oncologic outcome of the patients who were treated at Samsung Medical Center for their early glottic cancer during the last 20 years.
Methods: Five hundred ten patients were included for this study, who were diagnosed as a T1N0 or T2N0 glottic squamous cell carcinoma and firstly treated at Samsung Medical Center, Seoul, Korea, since 1994. The patients were divided into two groups; surgery-based (OP) treatment and radiation-based treatment (RT). The clinical characteristics, disease-free survival (DFS) and overall survival (OS) were compared between the two groups.
Results: The age and gender distribution were not significantly different between the two groups. (P>0.05) Regarding T-stage, proportion of T1/T2 was 88.0%/12.0% and 76.5%/23.5% in the OP and RT group, respectively. Treatment failure was observed in 16% (n=40/250) of OP group and 26.9% (n=70/260) of RT group (P=0.034). Local recurrence was the most common pattern of failure for both OP and RT group (n=26/40, 65% and n=44/70, 63%). In Kaplan-Meier survival analysis, 5-year DFS rate was significantly better in OP group than RT group (P=0.049). However, 5-year OS rate was not different. In multivariate logistic regression analysis, treatment modality (OP vs. RT) was the only significant risk factor for the recurrence (P=0.035, HR=1.648)
Conclusion: Retrospective analysis of 510 early-stage (T1N0, T2N0) glottic cancer patients showed that surgery-based treatment provides better DFS than radiation-based treatment.