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Immunobiology / Immunotherapy of H&N Cancer

B046

ANTI-OX-40 (MEDI6469) PRIOR TO DEFINITIVE SURGICAL RESECTION IN PATIENTS WITH HEAD AND NECK SQUAMOUS CELL CARCINOMA

Immunobiology / Immunotherapy of H&N Cancer

R. Bryan Bell, MD, DDS, FACS1, Rom S Leidner, MD1, Zipei Feng, MD, PhD2, Rebekka Duhen, PhD1, Yoshi Koguchi, PhD1, Carlo Bifulco, MD1, Bernard A Fox, PhD1, Brendan Curti, MD1, Andrew D Weinberg, PhD1

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1Earle A. Chiles Research Institute at Providence Cancer Center, 2Oregon Health & Science University

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B047

THE ROLE OF TLR3 SIGNALING IN CHEMORESISTANCE OF HEAD AND NECK SQUAMOUS CELL CARCINOMA

Immunobiology / Immunotherapy of H&N Cancer

Hui-Ching Chuang, MD, PhD

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Kaoshiung Chang Gung Memorial Hospital

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B048

LOSS OF PROTECTIVE CD169 MACROPHAGES IN LYMPH NODES WITH METASTATIC SQUAMOUS CELL CARCINOMA WITH PRESERVATION IN ADJACENT NEGATIVE DRAINING LYMPH NODES

Immunobiology / Immunotherapy of H&N Cancer

Michael C Topf, MD, Christopher M Shumrick, BS, Madalina Tuluc, MD, David M Cognetti, MD, Joseph M Curry, MD, Adam Luginbuhl, MD

Thomas Jefferson University Hospital

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B049

CETUXIMAB AND CISPLATIN EFFECTS ON OROSPHERE FORMATION AND GENE EXPRESSION IN HEAD AND NECK SQUAMOUS CELL CARCINOMA (HNSCC) CELLS: THE POTENTIAL FOR A PROGNOSTIC BIOMARKER

Immunobiology / Immunotherapy of H&N Cancer

Valeda Yong, BA1, Lechuang Chen, MD, PhD2, Ashlee Jeter, BS2, Chad Zender, MD, FACS3, Ge Jin, PhD2, Aaron Weinberg, DMD, PhD2

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1Case Western Reserve University School of Medicine, 2Case Western Reserve School of Dental Medicine - Biological Sciences, 3University Hospitals Cleveland Medical Center - ENT Institute


S032

PD-1 BLOCKADE PREVENTS THE DEVELOPMENT OF ORAL SQUAMOUS CELL CARCINOMA FROM CARCINOGEN-INDUCED PREMALIGNANT LESIONS

Immunobiology / Immunotherapy of H&N Cancer

Jin Wang1, Bingbing Wang1, Xiaoyuan Zhu1, Tongxin Xie1, Adel K El-Naggar2, Jeffrey N Myers1, Carlos Caulin1

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1Departments of Head and Neck surgery,The University of Texas MD Anderson Cancer Center, 2Department of Pathology, The University of Texas MD Anderson Cancer Center

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S033

POST-OPERATIVE IMMUNE CHECKPOINT BLOCKADE TO PREVENT CANCER RECURRENCE IN THE SURGICAL WOUND

Immunobiology / Immunotherapy of H&N Cancer

Nayeon Choi, MD, Hangyul Kim, MD, Jungjoo Lee, MD, Youngsang Cho, MD, Boyoung Kim, MD, Han-Sin Jeong, MD, PhD

Samsung Medical Center

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S074

AVELUMAB (ANTI-PD-L1) IN COMBINATION WITH CHEMORADIOTHERAPY (CRT) VS CRT IN FIRST-LINE TREATMENT OF LOCALLY ADVANCED SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK (LA-SCCHN): JAVELIN HEAD AND NECK 100 PHASE 3 TRIAL

Immunobiology / Immunotherapy of H&N Cancer

Nancy L Lee, MD1, Robert L Ferris, MD, PhD2, Kevin J Harrington, MD3, Robert I Haddad, MD4, Jean Bourhis, MD, PhD5, Makoto Tahara, MD, PhD6, Margarida Geraldes, PhD7, Dimitry S.A Nuyten, MD, PhD7, Zelanna Goldberg, MD7, Ezra Cohen, MD8

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1Memorial Sloan Kettering Cancer Center, 2University of Pittsburgh Medical Center, 3The Institute of Cancer Research Chester Beatty Laboratories, 4Dana-Farber Cancer Institute, Harvard Medical School, 5Centre Hospitalier Universitaire Vaudois (CHUV) University of Lausanne, 6National Cancer Center Hospital East, 7Pfizer Inc., 8Moores Cancer Center, University of California

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