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Systemic Therapy / Immunotherapy

D224

ACTIVATION OF STAT1 INDUCES INTERFERON-RELATED GENES AND MEDIATES CISPLATIN RESISTANCE IN HEAD AND NECK CANCER CELLS

Systemic Therapy / Immunotherapy

Hui-Ching Chuang, MDPh, D

Kaohsiung Chang Gung Memorial Hospital


D225

EXPRESSION PATTERNS AND PROGNOSTIC VALUE OF PD-L1 IN HEAD AND NECK SQUAMOUS CELL CARCINOMA

Systemic Therapy / Immunotherapy

Michael A Blasco, MD, Yue Xi, PhD, George H Yoo, MD, Ho-Sheng Lin, MD, Andrew M Fribley, PhD

Wayne State University


D226

LOW SKELETAL MUSCLE MASS PREDICTS THE POOR TREATMENT OUTCOME IN PATIENTS WITH HEAD AND NECK SQUAMOUS CELL CARCINOMA RECEIVING CONCURRENT CHEMORADIOTHERAPY

Systemic Therapy / Immunotherapy

Ryusuke Shodo, MD, PhD, Hiroshi Matsuyama, MD, PhD, Yushi Ueki, MD, Ryuichi Okabe, MD, Keisuke Yamazaki, MD, PhD, Kohei Honda, MD, PhD, Arata Horii, MD, PhD

Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences


D227

MACROPHAGE POLARIZATION IN METASTATIC AND ADJACENT NEGATIVE LYMPH NODES IN HEAD AND NECK SQUAMOUS CELL CARCINOMA

Systemic Therapy / Immunotherapy

Swar Vimawala, BS1, Michael C Topf, MD1, Madalina Tuluc, MD2, Stacey Mardekian, MD2, David M Cognetti, MD1, Joseph M Curry, MD1, Ulrich Rodeck, MD, PhD3, Adam Luginbuhl, MD1, Larry Harshyne, PhD4

1Department of Otolaryngology—Head and Neck Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA, 2Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA, 3Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA, 4Department of Cancer Biology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania, USA


D228

SEVERE WOUND COMPLICATIONS ASSOCIATED WITH ROBUST TREATMENT RESPONSE DURING LEVATINIB THERAPY FOR ADVANCED THYROID CANCER

Systemic Therapy / Immunotherapy

Tyler S Weaver, MD, Peter E Andersen, MD, Matthew H Taylor, MD, Maisie L Shindo, MD, Dana Madison, MD, PhD, Olga Shenashova, MD, PhD, Ryan J Li, MD

Oregon Health & Science University


D229

THE CHICK EMBRYO CHORIOALLANTOIC MEMBRANE (CAM): A PLATFORM FOR ASSESSING THE IN VIVO EFFICACY OF CHIMERIC ANTIGEN RECEPTOR (CAR) T CELL THERAPY IN HEAD AND NECK CANCER

Systemic Therapy / Immunotherapy

Emilie A Warren1, Kershena S Liao2, Hsuan-Chen Liu1, Caroline E Porter1, Masataka Suzuki1, Andrew G Sikora, MD1

1Baylor College of Medicine, 2The University of Texas Southwestern Medical Center


D230

WEE1 INHIBITOR AZD1775 ENHANCES BLOCKADE OF PD-1 IN HNSCC CELLS EXPRESSING HPV16 E6/E7 ONCOPROTEINS

Systemic Therapy / Immunotherapy

Hideaki Takahashi, MD, PhD, Antje Lindemann, PhD, Ameeta A Patel, Ismail M Meraz, PhD, Mourad Majidi, PhD, Abdullah A Osman, PhD, Jeffrey N Myers, MD, PhD

The University of Texas MD Anderson Cancer Center


D231

REAL-WORLD TREATMENT OUTCOMES IN THE ELDERLY JAPANESE PATIENTS WITH HEAD AND NECK CANCER (HNC): THE DIFFERENCE BETWEEN STANDARD AND NON-STANDARD THERAPIES

Systemic Therapy / Immunotherapy

Hidetaka Ikemiyagi, Goshi Nishimura, Daisuke Sano, Kenichiro Yabuki, Yasuhiro Arai, Yoshihiro Chiba, Teruhiko Tanabe, Daiki Morishita, Yohei Hiiragi, Natsumi Takao, Yoshihiro Aizawa, Yusuke Nojima, Hiromitsu Hatakeyama, Associate Professor, Nobuhiko Oridate, Professor

Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, Yokohama City University, Yokohama, Japan.


D232

CHARACTERIZATION OF THE TUMOR IMMUNE MICROENVIRONMENT DURING HEAD AND NECK SQUAMOUS CELL CARCINOMA PROGRESSION

Systemic Therapy / Immunotherapy

Subin Surendran, MS, PhD, Usama Aboelkheir, MD, William J Magner, MS, PhD, Wesley L Hicks Jr, MD, DDS, Amritha Suresh, MS, PhD, Moni A Kuriakose, MD

Roswell Park Cancer Institute