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Systemic Therapy / Immunotherapy

AHNS-016

CUMULATIVE SUPPRESSIVE INDEX AS A PREDICTOR OF RELAPSE FREE SURVIVAL AND OVERALL SURVIVAL IN HPV- ORAL SQUAMOUS CELL CARCINOMAS WITH NEGATIVE RESECTION MARGINS

Systemic Therapy / Immunotherapy

Lauren N Hum, MD, DMD1, Daniel Bethmann, MD2, Zipei Feng, MD, PhD3, Shu-Ching Chang, PhD4, Alexander Eckert, MD5, Claudia Wickenhauser, MD2, Bernard A Fox, PhD6, R. Bryan Bell, MD, DDS, FACS7

1Department of Oral and Maxillofacial Surgery, Oregon Health and Science University, Portland, OR, 2Institute of Pathology, Martin Luther University Halle-Wittenberg, Halle, Germany, 3Bobby R. Alford Department of Otolaryngology, Baylor College of Medicine, Baylor, TX, 4Medical Data Research Center, Providence St. Joseph's Health, Portland, OR, 5Department of Oral and Maxillofacial Plastic Surgery, Martin Luther University Halle-Wittenberg, Halle, Germany, 6Robert W. Franz Cancer Research Center, Earle A. Chiles Research Institute, Portland, OR, 7Providence Oral, Head and Neck Cancer Program and Clinic, Portland, OR


AHNS-068

COMBINED INHIBITION OF WEE1 AND RAD51 ENHANCES CELL KILLING IN HNSCC

Systemic Therapy / Immunotherapy

Antje Lindemann, Ameeta A Patel, Hideaki Takahashi, Lin Tang, Abdullah A Osman, Jeffrey N Myers

The University of Texas MD Anderson Cancer Center


AHNS-069

ROLE OF INDUCTION CHEMOTHERAPY FOR ORAL CAVITY SQUAMOUS CELL CARCINOMA

Systemic Therapy / Immunotherapy

Ahmed S Abdelmeguid, MD, PhD1, Natalie L Silver, MD, PhD2, Mongkol Boonsripitayanon, MD1, Renata Ferrarotto, MD1, Ann M Gillenwater1, Ehab Y Hanna, MD1

1University of Texas MD Anderson Cancer Center, 2University of Florida College of Medicine


AHNS-070

SAFETY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF NF-KB MEDIATED APOPTOSIS OF THE ANTI-INFLAMMATORY BOTANICAL DRUG APG-157 IN PATIENTS WITH ORAL SQUAMOUS CELL CARCINOMA

Systemic Therapy / Immunotherapy

Saroj Basak, PhD1, Marco Morselli, PhD1, Alakesh Bera, PhD2, Alexander Yoon, BS1, Meera Srivastava, PhD2, Kym F Faull, PhD1, Matteo Pellegrini, PhD1, Chan Jeong, BS1, Eri Srivatsan, PhD3, Marilene B Wang1

1UCLA, 2Uniformed Services University of Health Sciences, 3VA Greater Los Angeles Healthcare System


AHNS-072

ASSOCIATION OF NEUTROPHIL-TO-LYMPHOCYTE RATIO DYNAMICS AND OUTCOMES WITH IMMUNE CHECKPOINT INHIBITION IN HEAD AND NECK SQUAMOUS CELL CARCINOMA

Systemic Therapy / Immunotherapy

Marcus A Couey, MD, DDS1, Mark T Schmidt, BSc1, Allen C Cheng, MD, DDS2, Ashish A Patel, MD, DDS2, R. Bryan Bell, MD, DDS1, Tanguy Y Seiwert, MD3, Rom S Leidner, MD1

1Earle A. Chiles Research Institute at Robert W. Franz Cancer Center, Providence Cancer Institute, Portland, OR, 2Head and Neck Institute, Portland, OR, 3Department of Medicine, Section of Hematology/Oncology, The University of Chicago Medicine, Chicago, IL


AHNS-074

THE IMPACT OF NEOADJUVANT PRE-SURGICAL PD-1 INHIBITION ON THE IMMUNE PHENOTYPE IN PATIENTS WITH ORAL CAVITY CANCER.

Systemic Therapy / Immunotherapy

David M Neskey, MD, MSCR1, John Kaczmar, MD1, Hannah Knochelman, BS1, Megan Wyatt, BS1, Ying Xiong, PhD1, Michael Froehlich, BS1, Anvesh Kompelli, BS2, M. Rita Young, PhD1, Chrystal Paulos, PhD1

1Medical University of South Carolina, 2Louisiana State University ShreveportLouisiana State University Health - Shreveport School of Medicine


AHNS-QS-097

IDENTIFICATION OF ANTIGENS FOR A MULTIVALENT VACCINE FOR HEAD AND NECK SQUAMOUS CELL CARCINOMA

Systemic Therapy / Immunotherapy

Harrison A Cash, MD1, Jeffrey Houlton, MD1, Laura Riolobos, PhD2, Mary L Dises, MD2

1University of Washington, Department of Otolaryngology, 2University of Washington, Cancer Vaccine Institute


D224

ACTIVATION OF STAT1 INDUCES INTERFERON-RELATED GENES AND MEDIATES CISPLATIN RESISTANCE IN HEAD AND NECK CANCER CELLS

Systemic Therapy / Immunotherapy

Hui-Ching Chuang, MDPh, D

Kaohsiung Chang Gung Memorial Hospital


D225

EXPRESSION PATTERNS AND PROGNOSTIC VALUE OF PD-L1 IN HEAD AND NECK SQUAMOUS CELL CARCINOMA

Systemic Therapy / Immunotherapy

Michael A Blasco, MD, Yue Xi, PhD, George H Yoo, MD, Ho-Sheng Lin, MD, Andrew M Fribley, PhD

Wayne State University


D226

LOW SKELETAL MUSCLE MASS PREDICTS THE POOR TREATMENT OUTCOME IN PATIENTS WITH HEAD AND NECK SQUAMOUS CELL CARCINOMA RECEIVING CONCURRENT CHEMORADIOTHERAPY

Systemic Therapy / Immunotherapy

Ryusuke Shodo, MD, PhD, Hiroshi Matsuyama, MD, PhD, Yushi Ueki, MD, Ryuichi Okabe, MD, Keisuke Yamazaki, MD, PhD, Kohei Honda, MD, PhD, Arata Horii, MD, PhD

Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences