Plasmablastic lymphoma (PBL) is an aggressive non-Hodgkin's lymphoma that carries a poor prognosis. It is a unique AIDS-related lymphoma which was first described in the jaws and oral cavity of HIV-infected persons about a decade ago. PBL has since been diagnosed in non-HIV infected persons with the literature showing that there is no association between HIV status and survival rate. The prognosis is very poor and shows median survival rates of 7 to 34 months. We present a case of a 36-year-old HIV-positive patient presenting with a lesion of the upper lip with a right submandibular mass. His PMH was significant for Kaposi Sarcoma which had been treated with systemic chemotherapy. We will discuss the head and neck manifestations of PBL, his treatment, management along with overall morbidity and mortality rates of PBL.