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American Head & Neck Society
July 21-25, 2012
Metro Toronto Convention Centre
Toronto, ON, Canada


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PRIMARY LARYNGEAL LYMPHOMA AFTER CHEMO-RADIOTHERAPY

Presentation: P099
Topic: Larynx/Oral Cavity
Type: Poster
Date: Sunday - Tuesday, July 22 - 24, 2012
Session: Designated Poster viewing times
Authors: Ching Yee Chan, MBBS MRCS Glasg, Hin Ngan Tay, MBBS MRCS Edin MMed ORL FAMS ORL
Institution(s): Singapore General Hospital

A patient with previous laryngeal squamous cell carcinoma post chemo-irradiation 10 years ago presented with dysphagia and shortness of breath. Examination and radiological investigations showed a laryngeal mass which was biopsied twice with no conclusive evidence of tumor. The patient underwent a total laryngectomy and partial pharyngectomy with selective neck dissection. The final histology was diffuse large B cell lymphoma.
A review of the literature describes lymphoma of the larynx as a rare entity, involving less than 1% of all laryngeal tumors (Acta Otorrinolaringol Esp 2011). Several case reports have described an association with a background of chronic inflammation such as Sjogren’s syndrome, chronic laryngitis, Epstein-Barr virus infection and gastric Helicobacter pylori infection.
However, a case of primary laryngeal lymphoma arising on a background of prior laryngeal carcinoma with chemo-irradiation has not been reported before. This report aims to highlight the possibility of such an occurence as the treatment modalities for carcinoma and lymphoma are vastly different and have a direct impact on the patient’s survival outcome.


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