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American Head & Neck Society
Annual Meeting, April 10-11, 2013
JW Marriott Grande Lakes
Orlando, Florida

During the
Combined Otolaryngology Spring Meeting
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RECURRENT GENOMIC ALTERATIONS OF FHIT GENE WITH IMPACT ON LYMPHATIC METASTASIS IN EARLY ORAL SQUAMOUS CELL CARCINOMA

Presentation: P008
Topic: Basic Science - Molecular / Cellular Biology
Type: Poster
Date: Wednesday - Thursday, April 10 - 11, 2013
Session: Designated Poster viewing times
Authors: Inn-Chul Nam, MD, Young-Hoon Joo, MD, Kwang-Jae Cho, MD, Sung-Won Park, Yeon-Soo Lee, MD, Yeun-Jun Chung, MD, Min-Sik Kim, MD
Institution(s): The Catholic University of Korea

Objectives : To determine the role of genetic factors related to the lymph node metastasis (LNM) in early oral squamous cell carcinoma (OSCC).

Subjects and Methods : Array-based comparative genomic hybridization with individual gene-level resolution using primary tumor materials from 14 early OSCC patients with (n=7) or without (n=7) cervical LNM. To confirm the genomic copy number alterations, immunohistochenical stain was conducted in 30 early OSCC specimens.

Results : The number of recurrent (>25%) copy number alterations with LNM group is 34, whereas that without LNM group is 23 by array-based comparative genomic hybridization in the first cohort. We detected 10 recurrently altered regions (10 losses) associated with cervical LNM (p<0.05). Among them, loss of 3p14.2 for the FHIT gene was the most frequent one (5 out of 7 patients with LNM, 71.4%) and significantly associated with a worse disease specific survival (p=0.005). In the independent validation cohort of 30 early OSCC cases, loss of FHIT determined by an immunohistochenical analysis was associated with cervical LNM (p=0.032) and disease specific survival (p=0.045).

Conclusion : Copy number alterations of FHIT are associated with LNM and poor prognosis, and risk stratification based on the copy-number status of this gene is useful to select the optimal treatment strategy in early OSCC patients
 

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