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American Head & Neck Society
Translational Research Meeting

April 21-22, 2015

AHNS Annual Meeting
April 22-23, 2015 during the
Combined Otolaryngology Spring Meetings


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TRM ABSTRACTS

S021 MOLECULAR SCREENING FOR CANCER TREATMENT OPTIMIZATION IN HEAD AND NECK CANCER (MOSCATO 01): A PROSPECTIVE MOLECULAR TRIAGE TRIAL; INTERIM ANALYSIS OF 78 PATIENTS WITH RECURRENT OR METASTATIC HEAD AND NECK CANCERS
Personalized Patient Care - How Our Institution Does It
Ingrid Breuskin, Caroline Even, Ecaterina Ileana, Christophe Massard, Naima Lezghed, Ludovic Lacroix, Antoine Hollebecque, Rastislav Bahleda, Maud Ngo-Camus, Yohann Loriot, Nathalie Auger, Valerie Koubi-Pick, Thierry De Baere, Philippe Vielh, Vladimir Lazar, Marie-Cécile Le Deley, Catherine Richon, Joël Guigay, François Janot, Jean-Charles Soria, Charles Ferté
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Gustave Roussy
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S022 TARGETED SEQUENCING OF AN EPIDEMIOLOGICALLY LOW RISK PATIENT DEFINES FIBROBLAST GROWTH FACTOR FAMILY ABERRATIONS AS A DRIVER OF HEAD AND NECK SQUAMOUS CELL CARCINOMA
Personalized Patient Care - How Our Institution Does It
Brittny N Tillman, MD, Laura M Bou-Maroun, BS, Megan L Yanik, BS, Catherine S Grasso, Michael J Quist, Nallasivam Palanisamy, PhD, Shannon Carskadon, Thomas E Carey, PhD, Carol R Bradford, MD, Scott A Tomlins, MD, Jonathan B McHugh, MD, Matthew E Spector, MD, Chad Brenner, PhD
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University of Michigan
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S015 CHARACTERIZATION OF NOVEL GENE FUSIONS IN HUMAN PAPILLOMAVIRUS (HPV) RELATED OROPHARYNGEAL SQUAMOUS CELL CARCINOMA
HTS - Deep Sequencing Target and Pathways
Theresa Guo, MD1, Daria Gaykalova, PhD1, Michael Considine, MS2, Justin A Bishop, MD3, Julie Ahn, MS1, Samantha Gebhart, MS1, Marla Goldsmith, MS1, Zubair Khan, MD1, William H Westra, MD3, Wayne M Koch, MD1, Elana Fertig, PhD2, Joseph A Califano, MD1
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1Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins Medical Institutions, 2Oncology Biostatistics and Bioinformatics, Sidney Kimmel Comprehensive Cancer, Johns Hopkins Medical, 3Department of Pathology, Johns Hopkins Medical Institutions
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S016 FLUORESCENCE DETECTION OF SQUAMOUS CELL CARCINOMA AND ORAL DYSPLASIA WITH INDOCYANINE GREEN-LABELED CHLOROTOXIN
Tumor Imaging
Fred M Baik2, Chang Xu, PhD1, Eduardo Mendez, MD, MPH2
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2University of Washington Department of Otolaryngology - Head and Neck Surgery, 1Fred Hutchinson Cancer Research Center
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S008 A REGIMEN COMBINING THE WEE-1 INHIBITOR, AZD-1775 WITH THE HDAC INHIBITOR, VORINOSTAT IS HIGHLY ACTIVE AGAINST HEAD AND NECK SQUAMOUS CELL CARCINOMA HARBORING P53 MUTATIONS
Breakthroughs - Paradigm Changes New Thoughts, HNSCC & HPV
Natalie Silver, MD, MS1, Abdullah Osman, PhD1, Ameeta Patel1, Jiping Wang1, Noriaki Tanaka1, Mitchell Frederick, PhD1, Faye Johnson, MD, PhD2, Siqing Fu, MD, PhD3, Jeffrey Myers, MD, PhD1
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1UT MD Anderson Cancer Center- Department of Head and Neck Surgery, 2UT MD Anderson Cancer Center- Department of Thoracic/Head and Neck Medical Oncology, 3UT MD Anderson Cancer Center- Department of Investigational Cancer Therapeutics
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S009 INTRA-TUMOURAL HETEROGENEITY OF P53 EXPRESSION IN SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK.
Breakthroughs - Paradigm Changes New Thoughts, HNSCC & HPV
Sankalap Tandon1, Nazia Munir1, Jeff Lancaster1, Nick Roland1, Shaun R Jackson1, Tim Helliwell2, Mark Boyd3, Terry Jones4
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1University Hospital Aintree, Liverpool, UK, 2Royal Liverpool University Hospital, Liverpool, UK, 3Institute of Translational Medicine, University of Liverpool, Liverpool, UK, 4NWCR Centre, University of Liverpool, Liverpool, UK
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S012 THE ROLE OF ADIPOSE DERIVED STROMAL CELLS FOR REVERSAL OF RADIATION FIBROSIS
Maximizing Function after Treatment of HN Cancer
Xiao Zhao, MD1, Ju Hee Lee2, Laurie Ailles, PhD3, Kenneth Yip, PhD4, Fei-Fei Liu, MD, FRCPC5
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1Department of Otolaryngology, University of Toronto, 2University of Waterloo, 3Division of Stem Cell and Developmental Biology, Ontario Cancer Institute, 4University of Toronto, 5Department of Radiation Oncology, University of Toronto
S001 APPLICATION OF PRIMARY CULTURE OF SALIVARY GLAND BENIGN AND MALIGNANT TUMORS UNDER CONDITIONAL REPROGRAMMING CONDITIONS FOR DEFINITION OF TUMOR-ASSOCIATED GENETIC CHANGES
Salivary - What's New
Priscilla A Furth, MD1, Xuefeng Liu, MD1, Ahmad Alamri, MS1, Bhaskar V Kallakury, MD2, Kenneth Newkirk, MD2, Bruce Davidson, MD2
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1Georgetown University, 2Georgetown University and MedStar Georgetown University Hospital
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S023 CYCLIC DINUCLEOTIDE, A NOVEL ADJUVANT FOR SQUAMOUS CELL CARCINOMA
Late Breaking Hot Topics
Shekhar K Gadkaree, Rupashree Sen, Juan Fu, Clint Allen, Young J Kim
Department of Otolaryngology - Head & Neck Surgery, Johns Hopkins University School of Medicine
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S007 DNA METHYLATION REGULATES TMEM16A EXPRESSION THROUGH ALTERNATE MECHANISMS AT TWO DISTINCT CPG ISLANDS
Epigenetics in Cancer
Andrey Finegersh, PhD, Scott Kulich, MD, PhD, Ronak Dixit, Umamaheswar Duvvuri, MD, PhD
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University of Pittsburgh School of Medicine





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