Introduction: Angiosarcoma of the head and neck is a rare but aggressive vascular sarcoma associates with high rate of local recurrences and poor prognosis.  Various histological types would display different clinical behaviors. The aim of this study was to investigate the oncologic outcomes and prognostic factors of the head and neck angiosarcoma.

Material and Methods: From 1990 to 2015.12, we retrospectively chart-reviewed our patients treated in National Taiwan University Hospital. We evaluated our outcome by using univariate and multivariate analysis with localregional control (LRC), recurrence free survival (RFS) and overall survival (OS). We compared our results to the literature.

Results: We identified 63 patients with head and neck angiosarcoma treated at our institution. Mean follow up time was 57 months. Local recurrence rate was 61%. Five-year overall survival rate was 29%. Univariate analysis showed that age (>60), tumor size (>10cm) and surgical margin (>2cm) were significant prognostic factors (p<0.05) for overall survival.

Conclusion: Our data series showed that the head and neck angiosarcoma has high rates of recurrence and is associated with poor prognosis.  Age, tumor size and resection surgical margin significantly affected mortality rate.