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A PHASE 3, RANDOMIZED, OPEN-LABEL STUDY OF DURVALUMAB (MEDI4736) +/- TREMELIMUMAB, VERSUS STANDARD OF CARE (SOC), IN PLATINUM-RESISTANT RECURRENT OR METASTATIC (R/M) SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK (SCCHN): EAGLE

Chemotherapy / Radiation / Adjuvant Treatment

Robert L Ferris¹, Mikhail Dvorkin PhD², Jerome Fayette³, Paul Clement⁴, Caroline Even⁵, Eva Remenar⁶, Robert Haddad⁷, Makoto Tahara⁸, Trishna Goswami⁹, April Franks⁹, Ugochi Emeribe⁹, Giovanni Melillo⁹, Lisa Licitra¹⁰

¹Department of Otolaryngology and Cancer Immunology Program, University of Pittsburgh Cancer Institute, Pittsburgh, USA, ²Budgetary Healthcare Institution of Omsk Region "Clinical Oncologic Dispensary", ³Centre Léon Bérard, Lyon, France, ⁴Universitair Ziekenhuis Leuven, Leuven, Belgium, ⁵Head and Neck Oncology, Institut Gustave-Roussy, Villejuif, France, ⁶Országos Onkológiai Intézet, Budapest, Hungary, ⁷Dana Farber Cancer Institute, Boston, USA, ⁸Head and Neck Medical Oncology, National Cancer Center Hospital East, Kashiwa, Japan, ⁹Immuno-Oncology GMD, AstraZeneca, Gaithersburg, USA, ¹⁰Head and Neck Cancer Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

CISPLATIN-INDUCED OTOTOXICITY IN HEAD AND NECK CANCER: THE PATTERNS AND PREDICTION

Chemotherapy / Radiation / Adjuvant Treatment

Chiaki Suzuki, MD¹, Morimasa Kitamura, MD, PhD¹, Ichiro Tateya, MD, PhD¹, Shigeru Hirano¹, Satoshi Morita, PhD², Koichi Oomori, MD, PhD¹, Norio Yamamoto, MD, PhD¹

¹Department of Otolaryngology-Head & Neck Surgery, Kyoto University Graduate School of Medicine, ²Department of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine

ORAL UFUR IN ADVANCED ORAL CANCER

Chemotherapy / Radiation / Adjuvant Treatment

Ming-yu Hsieh, Mu-Kuan Chen

changhua christian hospital, Taiwan

EFFECTIVE IMMUNOTHERAPY OF HEAD AND NECK SQUAMOUS CELL CANCERS (HNSCC) IN MURINE MODELS WITH SYNTHETIC TLR AGONISTS COMBINED WITH CHEMOTHERAPY OR A CHECKPOINT INHIBITOR

Chemotherapy / Radiation / Adjuvant Treatment

Fumi Kaneko, PhD¹, Shiyin Yao¹, Shannon S Zhang¹, Judy Varner, PhD¹, Ezra Cohen, MD¹, Dennis A Carson, MD¹, Karen Messer, PhD¹, Minya Pu, MS¹, Cristiana Guiducci, PhD², Robert L Coffman, PhD², Tomoko Hayashi, MD, PhD¹

¹University of California, San Diego Moores Cancer Center, ²Dynavax Technologies

IS PD1/PD-L1 INHIBITOR A RADIO-SENSITIZER? ORAL CAVITY SCC CASE REPORT

Chemotherapy / Radiation / Adjuvant Treatment

Misako Nagasaka, Ammar W Sukari

Karmanos Cancer Institute

NECK DISSECTION FOR CERVICAL LYMPH NODE METASTASES FROM PRIMARIES NOT IN THE HEAD AND NECK

Chemotherapy / Radiation / Adjuvant Treatment

Hiroyuki Harada, Shogo Shinohara, Atsushi Suehiro, Keizo Fujiwara, Ippei Kishimoto, Fumihiko Kuwata, Kazuki Hayashi, Ryosuke Yamamoto, Yasushi Naito

Kobe City Medical Center General Hospital

PHOTOIMMUNOTHERAPY FOR THE TREATMENT OF RESIDUAL DISEASE AFTER INCOMPLETE RESECTION OF HEAD AND NECK SQUAMOUS CELL CARCINOMA

Chemotherapy / Radiation / Adjuvant Treatment

Lindsay S Moore, MD¹, Esther de Boer, BS¹, Matthew D Tucker, BS¹, William R Carroll, MD¹, Jason M Warram, PhD¹, Eben L Rosenthal, MD²

¹The University of Alabama at Birmingham, ²Stanford University

DOSE-ESCALATED RADIOSURGERY (SRS) BOOST FOR UNFAVORABLE LOCALLY ADVANCED OROPHARYNGEAL CANCER: ONCOLOGICAL AND FUNCTIONAL OUTCOMES OF PHASE I/II TRIAL

Chemotherapy / Radiation / Adjuvant Treatment

Maged Ghaly, MD, Aditya Halthore, MD, Jeffrey Antone, Honglai Zhang, Kristin Beadle, Vinh Nguyen, MD, Doru Paul, MD, Douglas Frank, MD

Hofstra Northwell School of Medicine

METABOLIC INTERROGATION AS A TOOL TO OPTIMIZE CHEMOTHERAPEUTIC REGIMENS

Chemotherapy / Radiation / Adjuvant Treatment

Vlad Sandulache, MD, PhD, Yunyun Chen, William William, MD, Heath Skinner, MD, PhD, Jeffrey Myers, MD, PhD, Raymond Meyn, MD, Lei Feng, Clifton Fuller, MD, PhD, James Bankson, Stephen Lai, MD, PhD

UT MD Anderson Cancer Center

ROLE OF ADJUVANT RADIOTHERAPY IN T1-2N0 STAGE II ORAL CAVITY CANCER PATIENTS: AN ANALYSIS OF 18,769 PATIENTS FROM THE NATIONAL CANCER DATABASE (NCDB).

Chemotherapy / Radiation / Adjuvant Treatment

Minh Tam Truong, MD¹, Muhammad M Qureshi, MBBS, MPH², Diana Kirke, MD¹, Waleed H Ezzat, MD¹, Andrew Salama, MD, DDS¹, Scharukh Jalisi, MD¹

¹Boston Medical Center, ²Boston University School of Medicine