Mucoepidermoid Carcinoma of the Parotid Gland: A National Cancer Data Base Study

Presentation: C139
Topic: Survivorship
Type: Poster
Date: Thursday, April 19, 2018
Session: 9:00 AM - 7:00 PM
Authors: Karthik Rajasekaran, MD, Vanessa Stubbs, MD, Jinbo Chen, PhD, Pratyusha Yalamanchi, BA, Steven Cannady, MD, Jason Brant, MD, Jason Newman, MD
Institution(s): University of Pennsylvania

Importance: Mucoepidermoid carcinoma is the most common parotid gland malignancy.  Unfortunately, there is a paucity of literature describing the epidemiology of mucoepidermoid carcinoma. 

Objective: To describe the demographics, tumor characteristics, and prognostic features of mucoepidermoid carcinoma of the parotid gland.

Design: Retrospective database review

Setting: National Cancer Database (2004-2012)

Participants: The National Cancer Database was reviewed for all mucoepidermoid carcinomas of the parotid gland.

Main outcomes and measures: Patient demographics and tumor characteristics were abstracted and analyzed.  Univariate and multivariate Cox multivariate regression models were used to identify predictors of survival. 

Results: A total of 4431 patients met inclusion criteria. Average age at diagnosis was 57 years (SD 19), with no overall sex preference (52% female), and majority white (78%).  The 1-year overall survival was 92.9% (95% CI [92.1-93.6]) and 5-year overall survival was 75.2% (95% CI [73.8-76.7%]).  Median overall survival was not reached at 5 years. Factors associated with decreased survival were increasing age, comorbidities, high tumor grade, advanced pathologic group stage, and positive surgical margins. Female sex was the only factor associated with improved survival. Controlling for either histopathologic grade or pathologic stage to determine how patient demographics and tumor characteristics affected overall survival yielded similar results. Of note, intermediate grade tumors, although not independently associated with worse survival, when seen in conjunction with tumors ≥T2 and/or ≥N2, a negative impact on overall survival was seen.

Conclusion and Relevance: Although mucoepidermoid carcinoma of the parotid gland is the most common parotid gland malignancy, it is still a rare tumor with a lack of large population-based studies.  Advanced stage and high-grade tumors are significant predictors of decreased survival.  Females have improved survival compared to males.