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THREE-DIMENSIONAL PATIENT DERIVED ORGANOIDS CAPTURE GENETIC AND EPIGENETIC FEATURES OF INTER- AND INTRA-TUMORAL HETEROGENEITY IN HEAD AND NECK CANCER

Cancer Biology

Anuraag S Parikh, MD¹; Samuel P Flashner, PhD¹; Ogoegbunam Okolo, BS¹; Cecilia Martin, MS¹; Spyros Karaiskos, PhD¹; Masataka Shimonosono, PhD¹; Xiao Chen, PhD¹; Kristjan Gretarsson, PhD¹; Victoria X Yu, MD¹; Salvatore M Caruana, MD¹; Scott H Troob, MD¹; Angela J Yoon, DDS²; Devraj Basu, MD³; Fatemeh Momen-Heravi, DDS, PhD¹; Andres Klein-Szanto, MD, PhD⁴; Chao Lu, PhD¹; Hiroshi Nakagawa, MD, PhD¹

¹Columbia University; ²Medical University of South Carolina; ³University of Pennsylvania; ⁴Fox Chase Cancer Center

DISCRETE CELL CLUSTERS WITHIN THE HEAD AND NECK SQUAMOUS CELL CARCINOMA TUMOR MICROENVIRONMENT DRIVE TUMOR GROWTH VIA IL-22 SIGNALING

Cancer Biology

Tolani F Olonisakin, MD, PhD¹; Purva Rumde, BA²; Chareeni Kurukulasuriya, BSc²; Monica Dayao, MEng³; Aaron Mayer, PhD⁴; Avani Vyas, PhD²; R. Alexander Harbison, MD¹; Umamaheswar Duvvuri, MD, PhD²

¹Johns Hopkins Hospital; ²University of Pittsburgh Medical Center; ³Carnegie Mellon University; ⁴Enable Medicine

TUMOR INFILTRATING LYMPHOCYTES PREDICT SURVIVAL AND IMMUNOTHERAPY RESPONSE IN RECURRENT/METASTATIC HEAD AND NECK SQUAMOUS CELL CARCINOMA

Cancer Biology

Catherine T Haring, MD¹; Joshua D Smith, MD²; Sarah M Dermody, MD²; Collin Brummel²; Matthew E Spector, MD²; J. Chad Brenner, PhD²; Paul L Swiecicki, MD²

¹The Ohio State University; ²University of Michigan

SLC7A5 LINKS AMINO ACID METABOLISM TO THE EPIGENOME OF HEAD AND NECK SQUAMOUS CELL CARCINOMA

Cancer Biology

1; Li-Yan Li²; Qian Yang²; Megha Sheth¹; Hua Zhao¹; Phillip Koeffler²; Li-Yan Xu³; En-Min Li³; Uttam Sinha¹; De-Chen Lin, PhD¹

¹University of Southern California; ²Cedars-Sinai Medical Center; ³Shantou Medical School

DEVELOPING A TARGETED THERAPY TO ENHANCE IMMUNE RESPONSES IN NSD1-MUTATED SQUAMOUS CELL CARCINOMA

Cancer Biology

Joanne Soo, MD¹; Chen Chen, MD, PhD¹; June Ho Shin, PhD¹; Ravindra Uppaluri, MD, PhD²; Bruce Koch³; John B Sunwoo¹

¹Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA; ²Division of Otolaryngology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ³Sarafan ChEM-H, Stanford University School of Medicine, Stanford, CA

MACROPHAGE PD-L1 EXPRESSION IS INCREASED BY TOLL-LIKE RECEPTOR ACTIVATION WITH SELECT ORAL BACTERIA

Cancer Biology

Olivia L Ricks, RN, BSN¹; Juhi J Patel²; Zoë E Evans³; Gabriela S Fonseca¹; Sarah I Elimam³; Shilpa M Rao, MD²; Yolanda E Hartman²; Adia Ingram, MS²; Jason M Warram, PhD²; Carissa M Thomas, MD, PhD²

¹Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL; ²Department of Otolaryngology - Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL; ³Cancer Biology Program, University of Alabama at Birmingham, Birmingham, AL

EFFECTS OF IL-17 NEUTRALIZATION IN A MURINE MODEL OF HPV-POSITIVE HEAD AND NECK SQUAMOUS CELL CARCINOMA

Cancer Biology

Stephanie Wong, MD; Ruben Prins, MS; Martin Kast, PhD

University of Southern California

VALIDATION OF A SALIVA-LIQUID BIOPSY TEST (HNKLEAR) FOR HEAD AND NECK SQUAMOUS CELL CARCINOMA

Cancer Biology

1; Yue Qiu¹; Evangelina Espinoza¹; Sophie Gerndt²; Andrew Lu¹; Avery Allen¹; Dexiang Gao¹; Brian Harry¹; Neil Gross³; John Song¹; Sophia Bornstein⁴; Jose Zevallos²; Shi-Long Lu¹

¹University of Colorado; ²Washington University; ³MD Anderson Cancer Center; ⁴Celilo Cancer Center

TRACHEAL CHONDROSARCOMA: A NOVEL PRESENTATION OF LYNCH SYNDROME

Cancer Biology

Akash Bhat¹; Sophie Gerndt²; Ariel Sandhu³; Alexander M Helfand⁴; Rahim Jiwani⁴; Garren M Low²

¹Drexel University School of Medicine; ²Allegheny Health Network, Division of Otolaryngology Head and Neck Surgery; ³Allegheny Health Network, Department of Pathology; ⁴Allegheny Health Network, Department of Internal Medicine, Division of Medical Oncology

PATHWAYS OF HNSCC CARCINOGENESIS: A RESULTS FROM BIOINFORMATIC ANALYSIS OF NEXT GENERATION SEQUENCING DATA.

Cancer Biology

Shweta Shweta, Dr; Manoj Pandey, Prof

Institute of Medical Sciences, Banaras Hindu University