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THE IMPACT OF SMOKING ON 5-YEAR RECURRENCE-FREE AND OVERALL SURVIVAL IN AN INSTITUTIONAL COHORT OF HPV+ OROPHARYNGEAL CANCER TREATED FROM 2012-2019

Oropharynx / HPV Related Disease

Sarah G Wilkins, BS; Rema Shah, BS; Hemali P Shah, BS; Conrad W Safranek, BS; Saral Mehra, MD, MBA, FACS

Yale University

SURVIVAL AND FUNCTIONAL OUTCOMES IN PATIENTS RECEIVING PRIMARY SURGERY VERSUS CHEMORADIATION FOR T1/T2 OROPHARYNGEAL SQUAMOUS CELL CARCINOMA

Oropharynx / HPV Related Disease

Dev R Amin, MD; Ramez Philips, MD; Zachary Urdang, MD, PhD; Eric Mastrolonardo, MD; Sruti Tekumalla; Adam Luginbuhl, MD; David Cognetti, MD; Joseph Curry

Thomas Jefferson University Hospital

IMPACT OF POST-OPERATIVE TORS HEMORRHAGE ON ADJUVANT TREATMENT DELAYS IN PATIENTS WITH OROPHARYNGEAL SQUAMOUS CELL CARCINOMA

Oropharynx / HPV Related Disease

1; Daniel Awad, MS²; Xiaosu Liu²; Mark Kubik, MD¹; Seungwon Kim, MD¹; Robert Ferris, MD¹; Umamaheswar Duvvuri¹; Shaum S Sridharan, MD¹

¹UPMC; ²University of Pittsburgh School of Medicine

PATTERNS OF POST-OPERATIVE IMAGING SURVEILLANCE AND FINDINGS FOLLOWING SURGICAL MANAGEMENT OF HPV(+)OPSCC

Oropharynx / HPV Related Disease

Agnes Q Zhu¹; Claire E Cassianni¹; Travis Haller²; Eric J Moore²; Daniel L Price²; Kendall K Tasche²; Linda X Yin³; Daniel J Ma⁴; Scott C Lester⁴; Mauricio Gamez⁴; Michelle A Neben Wittich⁴; Katherine A Price⁵; David M Routman⁴; Kathryn M Van Abel²

¹Mayo Clinic Alix School of Medicine; ²Mayo Clinic Otolaryngology (ENT) Department; ³University of Michigan Otolaryngology Department; ⁴Mayo Clinic Radiation Oncology Department; ⁵Mayo Clinic Medical Oncology Department

PROLONGED DIAGNOSIS-TO-TREATMENT INTERVAL AND DECREASED OVERALL SURVIVAL IN BLACK PATIENTS WITH HPV-ASSOCIATED OROPHARYNGEAL SQUAMOUS CELL CARCINOMA USING THE NATIONAL CANCER DATABASE

Oropharynx / HPV Related Disease

Margaret Nurimba, MD; Mark Swanson, MD; Tamara Chambers, MD

University of Southern California Keck School of Medicine

UPFRONT NECK DISSECTION ENHANCES TREATMENT SELECTION AND IMPROVES QUALITY OF LIFE IN A NOVEL TREATMENT PARADIGM FOR DEINTENSIFICATION IN STAGE I/II HPV+ OPSCC

Oropharynx / HPV Related Disease

1; Emily Bellile¹; Molly Heft Neal¹; Aleksandar Dragovic¹; Jonathon McHugh¹; Aaron Udager¹; Michelle Mierzwa¹; Caitlin Schonewolf¹; Jennifer Shah¹; Andrew Rosko¹; Kelly Malloy¹; Kieth Casper¹; Steve Chinn¹; Andrew Shuman¹; Chaz Stucken¹; Gregory Wolf¹; Carol Bradford²; Avraham Eisbruch¹; Mark Prince¹; Frank Worden¹; Matthew Spector¹

¹University of Michigan; ²The Ohio State University

ENHANCED TUMOR-SPECIFIC T CELL IMMUNITY FOLLOWING NEOADJUVANT CHEMOTHERAPY IN PATIENTS WITH NEWLY DIAGNOSED OROPHARYNGEAL CANCER ASSOCIATED WITH HPV

Oropharynx / HPV Related Disease

1; Jay Friedman¹; Cem Sievers¹; Brandon Shaver²; Punam Thakkar²; Joseph Goodman²; Arjun S Joshi²; Clint Allen¹

¹National Institutes of Health; ²George Washington University

CTDNA FOR MONITORING TREATMENT RESPONSE IN HPV-POSITIVE OROPHARYNGEAL SQUAMOUS CELL CARCINOMA PATIENTS

Oropharynx / HPV Related Disease

Sarah Tadhg Ferrier, MSc¹; Thupten Tsering, MSc¹; Kyle Dickinson, PhD¹; Anthony Zeitouni, Dr²; Nader Sadeghi, Dr²; Julia V Burnier, PhD¹

¹Research Institute of the McGill University Health Centre; ²McGill University Health Centre

HIGH EXPRESSION OF USP4 MRNA IS ASSOCIATED WITH OVERALL SURVIVAL AND HPV STATUS IN HEAD AND NECK SQUAMOUS CELL CARCINOMA PATIENTS

Cancer Biology

Alexandra Scheiflinger, MD¹; Sega Al-Gboore²; Bernhard J. Jank, MD²; Faris Brkic, MD²; Lorenz Kadletz-Wanke, MD²; Lukas Kenner, MD³; Gregor Heiduschka, Prof, MD²; Julia Schnoell, MD²

¹Department of Surgery, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA; ²Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria; ³Department of Pathology, Medical University of Vienna, Vienna, Austria

REAL-WORLD NGS IN PATIENTS WITH HEAD AND NECK SQUAMOUS CELL CARCINOMA

Cancer Biology

Eric Bhang¹; Stephen Yip²; Marjan Kamali Sarvestani¹; Fatima Usman¹; Deepu Alex²; Tony Ng²; Barbara Campling³; Krista Noonan⁴; Ann Tan⁵; Sunil Parimi⁶; Janessa Laskin¹; Howard Lim¹; Steven Chia¹; Jason KoLeong¹; Shira Sabag¹; Samantha Pollard⁷; Deirdre Weymann⁷; Dean Regier⁷; Cheryl Ho¹; Nicole Chau¹

¹Department of Medical Oncology, BC Cancer, Vancouver, BC, Canada; ²Department of Pathology & Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; ³Department of Medical Oncology, BC Cancer, Kelowna, BC, Canada; ⁴Department of Medical Oncology, BC Cancer, Surrey, BC, Canada; ⁵Department of Medical Oncology, BC Cancer, Abbotsford, BC, Canada; ⁶Department of Medical Oncology, Victoria, BC, Canada; ⁷Department of Cancer Control Research, BC Cancer, Vancouver, BC, Canada