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MARCH6 PROMOTES PAPILLARY THYROID CANCER DEVELOPMENT BY DESTABILIZING DHX9

Cancer Biology

Yang Liu, MD; Siyuan Xu; Ying Huang, MD; Shaoyan Liu; Zhengang Xu; Jie Liu, MD

Department of Head and Neck Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

THE RS6942067 GG GENOTYPE IS ASSOCIATED WITH A WORSE OVERALL SURVIVAL IN HEAD AND NECK SQUAMOUS CELL CARCINOMA AND WITH N+ PATIENTS EITHER UNDER 42 YEARS OLD OR NON-SMOKING HPV NEGATIVE

Cancer Biology

Guillaume B. Cardin¹; Monique Bernard¹; Houda Bahig²; Felix-Phuc Nguyen-Tan²; Edith Filion²; Denis Soulieres²; Danielle Charpentier²; Olguta Gologan²; Tareck Ayad²; Louis Guertin²; Eric Bissada²; Jean-Claude Tabet²; Francis Rodier¹; Apostolos Christopoulos²

¹Centre de Recherche du Centre Hospitalier de l'Université de Montréal; ²Centre hospitalier de l'Université de Montréal

THE SPECTRUM OF TUMOR MUTATIONAL BURDEN IN A HEAD AND NECK CANCER COHORT

Cancer Biology

1; Jacob Friedman, MD¹; Michael Jelinek, MD²; Mary Jo Fidler, MD²; Nikhil Joshi, MD³; Kerstin Stenson, MD¹; Mihir Bhayani, MD¹; Samer Al-Khudari¹

¹Department of Otorhinolaryngology - Head and Neck Surgery, Rush University Medical Center; ²Department of Internal Medicine - Medical Oncology, Rush University Medical Center; ³Department of Radiation Oncology, Rush University Medical Center

EFFECT OF OPIOID RECEPTOR ACTIVATION AND BLOCKAGE ON THE PROGRESSION AND RESPONSE TO TREATMENT OF HEAD AND NECK SQUAMOUS CELL CARCINOMA

Cancer Biology

Lirit Levi, MD¹; Hagit Shoffel-Havakuk, MD¹; Elad Hikri, MD, PHD²; Avraham Dayan²; Aron Popovtzer³; Gideon Bachar¹; Aviram Mizrachi¹

¹Department of Otorhinolaryngology - Head and Neck Surgery, Rabin Medical Center, Petach Tikva, Israel; ²Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; ³Institute of Oncology, Hadassah Medical Center and the Hebrew University, Jerusalem, Israel

HYPOXIA INDUCIBLE FACTOR (HIF - 1 ALPHA) EXPRESSION AS AN INDICATOR OF CLINICO-PATHOLOGICAL CHARACTERISTICS & ITS PROGNOSTIC SIGNIFICANCE IN SQUAMOUS CELL CARCINOMA OF TONGUE.

Cancer Biology

Harish Eshwarappa, MS, MCh; Elizabeth M Iype; Lakshmi S

Regional Cancer Centre, Thiruvananthapuram

IDO1 AND CXCL11 MRNA GENE EXPRESSIONS, ADJUSTED FOR TP53 GENOMIC ABERRATIONS AND PD1/PDL1 MRNA GENE EXPRESSIONS, ARE PROGNOSTIC IN PATIENTS WITH STAGE III-IVB HPV-NEGATIVE HNSCC

Cancer Biology

Evan M De Joya, BS; Stuart E Samuels, MD, PhD; Gregory A Azzam, MD, PhD; Laura M Freedman, MD; Susan H Blanton, PhD; Cesar A Perez, MD; Zoukaa B Sargi, MD, MPH; Michael Samuels, MD; Ruben Carmona, MD, MAS

University of Miami, Miller School of Medicine

NY-ESO-1 EXPRESSION IN ORAL PRE-MALIGNANT AND MALIGNANT LESIONS

Cancer Biology

William J Magner, PhD¹; Subin Surendran, PhD¹; Vishal Gupta, MD¹; Kimberly Wooten, MD¹; Ryan P McSpadden, MD¹; Jon Chan, MD¹; S. Lynn Sigurdson, PhD¹; Mihai Merzianu, MD¹; Wesley L Hicks Jr, DDS, MD¹; Adekunle O Odunsi, MD, PhD¹; Moni A Kuriakose²; Amritha Suresh, PhD²

¹Roswell Park Comprehensive Cancer Center; ²Mazumdar Shaw Medical Center-Roswell Park Collaboration Program, Bangalore India

ACTIN-ASSOCIATED GENE EXPRESSION IS ASSOCIATED WITH EARLY REGIONAL METASTASIS OF TONGUE CANCER.

Cancer Biology

Young Kang, MD¹; Doh Young Lee, MD²; Dong Wook Lee, MD, PhD¹

¹Department of Otorhinolaryngology Head and Neck Surgery, Chungbuk National University College of Medicine, Chungbuk National University Hospital, Cheongju, Republic of Korea; ²Department of Otorhinolaryngology Head and Neck Surgery, Seoul Nation University Boramae Medical Center, Seoul, South Korea

NOVEL ANAPLASTIC THYROID CANCER PATIENT-DERIVED XENOGRAFT MODELS AND CELL LINES: EXPANDING THE MOLECULAR DIVERSITY OF IN VITRO AND IN VIVO MODELS

Cancer Biology

Anastasios Maniakas, MD, MSc¹; Ying C Henderson, MD, PhD²; Hu Hei, MD²; Shaohua Peng, PhD²; Yunyun Chen, PhD²; Yujie Jiang, BS²; Shuangxi Ji, PhD²; Maria Cardenas, BA³; Yulun Chiu, PhD²; Diana Bell, MD²; Michelle D Williams, MD²; Marie-Claude Hofmann, PhD²; Steve E Scherer, PhD³; David A Wheeler, PhD³; Naifa L Busaidy, MD²; Ramona Dadu, MD²; Jennifer R Wang, MD, MSc²; Maria E Cabanillas, MD²; Mark Zafereo, MD²; Faye M Johnson, MD, PhD²; Stephen Y Lai, MD, PhD²

¹Université de Montréal - Hôpital Maisonneuve-Rosemont; MD Anderson Cancer Center; ²MD Anderson Cancer Center; ³Baylor College of Medicine

NOVEL MEDIATORS OF THE P63-DRIVEN ONCOGENIC PROCESSES IN SQUAMOUS CELL CARCINOMA

Cancer Biology

Alexandra Glathar; Akinsola Oyelakin; Christian Gluck, MD, PhD; Satrajit Sinha, PhD

University at Buffalo