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FEASIBILITY OF SALIVA TESTING USING METHYLATED MICRORNAS FOR HEAD AND NECK SQUAMOUS CELL CARCINOMA RECURRENCE

Cancer Biology

1; Wafik Sedhom, MD¹; Derek Smith¹; Francis Hall, MD¹; Vivian Wu, MD¹; Ling Lu, PhD¹; Elyse Handley¹; Dexiang Gao, PhD¹; Sophia Bornstein, MD, PhD²; Neil Gross, MD³; Brian Harry, MD, PhD¹; Jose Zevallos, MD⁴; John Song, MD¹; Shi-Long Lu, MD, PhD¹

¹University of Colorado; ²Oregon Health and Science University; ³MD Anderson Cancer Center; ⁴Washington University

ROLE OF AXL AND EPITHELIAL-MESENCHYMAL TRANSITION IN CLASSIC AND MIXED VARIANTS OF ANAPLASTIC THYROID CANCER

Cancer Biology

1; Rebecca R Pharaon, BA²; Kimberley-Jane C Bonjoc, BS²; Feras Ally, MD²; Holly Yin, PhD²; Robert Kang, MD²; Thomas Gernon, MD²; Ellie Maghami, MD²; Ammar Chaudhry, MD²

¹University of Utah; ²City of Hope National Medical Center

TARGETING TUMOR METABOLISM THROUGH LACTATE DEHYDROGENASE A INHIBITS TUMOR PROGRESSION IN ANAPLASTIC THYROID CANCER XENOGRAFTS

Cancer Biology

Yunyun Chen, PhD¹; Meng Cui, MD, PhD¹; Xiangdong Le, MS¹; Joshua S Niedzielski, PhD²; Anastasios Maniakas, MD, MSc¹; Ying C Henderson, MD, PhD¹; Jim Bankson, PhD²; Vlad Sandulache, MD, PhD³; Stephen Y Lai, MD, PhD¹

¹Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; ²Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; ³Department of Otolaryngology - Head and Neck Surgery, Baylor College of Medicine, Houston, TX, USA

SUBSITE SPECIFIC PROTEOMIC ANALYSIS OF ORAL SQUAMOUS CELL CARCINOMA TO IMPROVE TREATMENT AND OUTCOMES

Cancer Biology

Subin Surendran, PhD¹; William J Magner, PhD¹; S. Lynn Sigurdson, PhD¹; Vishal Gupta, MD¹; Wesley L Hicks, Jr, DDS, MD¹; Keith L Kirkwood, DDS, PhD²; Amritha Suresh, PhD³; Moni A Kuriakose, MD³

¹Roswell Park Comprehensive Cancer Center; ²University at Buffalo School of Dental Medicine; ³Mazumdar Shaw Medical Center- Roswell Park Collaboration Program

EVALUATION OF APOPTOSIS SIGNALING IN HEAD AND NECK SQUAMOUS CELL CARCINOMA (HNSCC) DEMONSTRATES DEPENDENCE ON BCL-FAMILY PRO-SURVIVAL MOLECULES

Cancer Biology

Daniel Li¹; Andrea Lopez, PhD²; Denis Reyna, PhD²; Carlos Thomas¹; Nitisha Shrivastava, PhD¹; Cory Fulcher, MD³; Michael B Prystowsky, MD, PhD¹; Evripidis Gavathiotis, PhD²; Thomas J Ow, MD, MS³

¹Albert Einstein College of Medicine, Department of Pathology; ²Albert Einstein College of Medicine, Department of Biochemistry; ³Montefiore Medical Center, Department of Otorhinolaryngology-Head and Neck Surgery

OVEREXPRESSION OF ENO1 PROMOTES THYROID CANCER GROWTH BY REGULATING CYSTATIN 1 AND CYSTATIN 4

Cancer Biology

Yang Liu; Jie Liu; Shaoyan Liu

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical, Sciences and Peking Union Medical College

UNCOVERING ANATOMICAL SUBSITE SPECIFIC TRANSCRIPTIONAL NETWORKS IN ORAL CAVITY SQUAMOUS CELL CARCINOMA

Cancer Biology

Christian Gluck, PhD¹; Michael R Markiewicz, MD, DDS, MPH¹; Amritha Suresh, PhD²; Moni A Kuriakose, MD²; William J Magner, PhD¹; Lynn Sigurdson¹; Ryan P McSpadden, MD¹; Anurag K Singh, MD¹; Satrajit Sinha, PhD³; Wesley L Hicks, Jr, DDS, MD¹

¹Roswell Park Comprehensive Cancer Center; ²Mazumdar Shaw Medical Center- Roswell Park Collaboration Program; ³University at Buffalo

METHYLATION AND GENE EXPRESSION DIFFERENCES BETWEEN ASC/TMS1 AND MYD88 GENES IN HEALTHY AND CANCER LARYNGEAL TISSUE

Cancer Biology

Mario Bilic¹; Lana Kovac Bilic¹; Jelena Knezevic²; Maja Sutic²

¹University Hospital Center Zagreb, Croatia; ²Ruder Boskovic Institute Zagreb, Croatia

ACETYL ISOGAMBOGIC ACID INDUCES ER STRESS AND CELL DEATH IN ORAL CAVITY CANCER CELLS

Cancer Biology

Thomas Jetmore, MD; William Mason; Andrew Fribley

Wayne State University

EXTENSIVE RESECTION OF NEWLY REPLICATED DNA IN IRRADIATED HPV-POSITIVE HNSCC CELL LINES

Cancer Biology

Christian S Betz; Janine Burmester; Malte Kriegs; Sabrina Christiansen; Kai Rothkamm; Thorsten Rieckmann

University Medical Center Hamburg-Eppendorf