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Cancer Biology

P054

THERAPEUTIC TARGETING OF GLUTAMINOLYSIS AND MITOCHONDRIAL TCA CYCLE IN HEAD AND NECK CANCER

Cancer Biology

Yong Teng1; LW Lang2; R Loveless2; LL He2; Chloe Shay1

1Emory University; 2Augusta University


P053

EXTENSIVE RESECTION OF NEWLY REPLICATED DNA IN IRRADIATED HPV-POSITIVE HNSCC CELL LINES

Cancer Biology

Christian S Betz; Janine Burmester; Malte Kriegs; Sabrina Christiansen; Kai Rothkamm; Thorsten Rieckmann

University Medical Center Hamburg-Eppendorf


P052

ACETYL ISOGAMBOGIC ACID INDUCES ER STRESS AND CELL DEATH IN ORAL CAVITY CANCER CELLS

Cancer Biology

Yue Xi, PhD; Chester Gauss; Mehrnoosh Ghafouri AbbasAbadi; Thomas Jetmore, MD; William Mason; Andrew Fribley

Wayne State University


P050

METHYLATION AND GENE EXPRESSION DIFFERENCES BETWEEN ASC/TMS1 AND MYD88 GENES IN HEALTHY AND CANCER LARYNGEAL TISSUE

Cancer Biology

Mario Bilic1; Lana Kovac Bilic1; Jelena Knezevic2; Maja Sutic2

1University Hospital Center Zagreb, Croatia; 2Ruder Boskovic Institute Zagreb, Croatia


P049

UNCOVERING ANATOMICAL SUBSITE SPECIFIC TRANSCRIPTIONAL NETWORKS IN ORAL CAVITY SQUAMOUS CELL CARCINOMA

Cancer Biology

Christian Gluck, PhD1; Michael R Markiewicz, MD, DDS, MPH1; Amritha Suresh, PhD2; Moni A Kuriakose, MD2; William J Magner, PhD1; Lynn Sigurdson1; Ryan P McSpadden, MD1; Anurag K Singh, MD1; Satrajit Sinha, PhD3; Wesley L Hicks, Jr, DDS, MD1

1Roswell Park Comprehensive Cancer Center; 2Mazumdar Shaw Medical Center- Roswell Park Collaboration Program; 3University at Buffalo


P048

OVEREXPRESSION OF ENO1 PROMOTES THYROID CANCER GROWTH BY REGULATING CYSTATIN 1 AND CYSTATIN 4

Cancer Biology

Yang Liu; Jie Liu; Shaoyan Liu

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical, Sciences and Peking Union Medical College


P047

EVALUATION OF APOPTOSIS SIGNALING IN HEAD AND NECK SQUAMOUS CELL CARCINOMA (HNSCC) DEMONSTRATES DEPENDENCE ON BCL-FAMILY PRO-SURVIVAL MOLECULES

Cancer Biology

Daniel Li1; Andrea Lopez, PhD2; Denis Reyna, PhD2; Carlos Thomas1; Nitisha Shrivastava, PhD1; Cory Fulcher, MD3; Michael B Prystowsky, MD, PhD1; Evripidis Gavathiotis, PhD2; Thomas J Ow, MD, MS3

1Albert Einstein College of Medicine, Department of Pathology; 2Albert Einstein College of Medicine, Department of Biochemistry; 3Montefiore Medical Center, Department of Otorhinolaryngology-Head and Neck Surgery


P045

SUBSITE SPECIFIC PROTEOMIC ANALYSIS OF ORAL SQUAMOUS CELL CARCINOMA TO IMPROVE TREATMENT AND OUTCOMES

Cancer Biology

Subin Surendran, PhD1; William J Magner, PhD1; S. Lynn Sigurdson, PhD1; Vishal Gupta, MD1; Wesley L Hicks, Jr, DDS, MD1; Keith L Kirkwood, DDS, PhD2; Amritha Suresh, PhD3; Moni A Kuriakose, MD3

1Roswell Park Comprehensive Cancer Center; 2University at Buffalo School of Dental Medicine; 3Mazumdar Shaw Medical Center- Roswell Park Collaboration Program


P044

TARGETING TUMOR METABOLISM THROUGH LACTATE DEHYDROGENASE A INHIBITS TUMOR PROGRESSION IN ANAPLASTIC THYROID CANCER XENOGRAFTS

Cancer Biology

Yunyun Chen, PhD1; Meng Cui, MD, PhD1; Xiangdong Le, MS1; Joshua S Niedzielski, PhD2; Anastasios Maniakas, MD, MSc1; Ying C Henderson, MD, PhD1; Jim Bankson, PhD2; Vlad Sandulache, MD, PhD3; Stephen Y Lai, MD, PhD1

1Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; 2Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; 3Department of Otolaryngology - Head and Neck Surgery, Baylor College of Medicine, Houston, TX, USA


P043

ROLE OF AXL AND EPITHELIAL-MESENCHYMAL TRANSITION IN CLASSIC AND MIXED VARIANTS OF ANAPLASTIC THYROID CANCER

Cancer Biology

Hannah J Young, BS1; Rebecca R Pharaon, BA2; Kimberley-Jane C Bonjoc, BS2; Feras Ally, MD2; Holly Yin, PhD2; Robert Kang, MD2; Thomas Gernon, MD2; Ellie Maghami, MD2; Ammar Chaudhry, MD2

1University of Utah; 2City of Hope National Medical Center